Pharmacokinetics of Cyproheptadine and Its Metabolites in Rats.
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چکیده
منابع مشابه
Pharmacokinetics of Tyrosol Metabolites in Rats.
Tyrosol is considered a potential antioxidant; however, little is known regarding the pharmacokinetics of its metabolites. To study the pharmacokinetics of tyrosol-derived metabolites after oral administration of a single dose of tyrosol, we attempted to identify tyrosol metabolites in rat plasma by using ultra-performance liquid chromatography and quadrupole time-of-flight mass spectrometry (U...
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The stereoselective pharmacokinetic of Tramadol (T) and its main metabolites concerning the influence of CYP2D6 phenotype and gender on the phase I metabolism of this compound was studied after administration of 100 mg single oral dose of racemic T to 24 male and female subjects. The pharmacokinetic parameters were estimated from plasma concentrations of the analytes enantiomers. The metabolic ...
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The stereoselective pharmacokinetic of Tramadol (T) and its main metabolites concerning the influence of CYP2D6 phenotype and gender on the phase I metabolism of this compound was studied after administration of 100 mg single oral dose of racemic T to 24 male and female subjects. The pharmacokinetic parameters were estimated from plasma concentrations of the analytes enantiomers. The metabolic ...
متن کاملEffects of Rutaecarpine on the Pharmacokinetics of Caffeine and Its Three Metabolites in Rats
metabolized by hepatic CYP1A2 and CYP2E1 (Caubet et al., 2004). Thereby, N-demethylations of caffeine have been used as marker reactions for some CYPs: 3-N-demethylation to paraxanthine catalyzed by CYP1A2 and 1-N-demethylation to theobromine and 7-N-demethylation to theophylline catalyzed by CYP2E1. Furthermore, caffeine and its three major metabolites have also been used as a tool for studyin...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 1993
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.16.1276